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  • Title: Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes Initiated by Radical Alkylation with Tertiary α-Carbonyl Alkyl Bromides.
    Author: Jin W, Zhou Y, Zhao Y, Ma Q, Kong L, Zhu G.
    Journal: Org Lett; 2018 Mar 02; 20(5):1435-1438. PubMed ID: 29436837.
    Abstract:
    A novel nickel-catalyzed remote arylation of alkenyl aldehydes triggered by radical alkylation with tertiary α-carbonyl alkyl bromides is described, thus producing a quaternary carbon center containing ketones in promising yields with broad functional group compatibility. Preliminary mechanistic studies suggest that the combination of a 1,n-HAT (n = 5 or 6) from alkyl radicals to aldehyde C-H bonds with nickel catalysis may account for the realization of this reaction.
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