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  • Title: Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species.
    Author: Youssef DTA, Alahdal AM.
    Journal: Molecules; 2018 Feb 12; 23(2):. PubMed ID: 29439550.
    Abstract:
    The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro-S-Phe) (3) and cyclo(R-Pro-R-Phe) (4). The structures of compounds 1-4 were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds 2-4 displayed variable cytotoxic and antimicrobial activities.
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