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  • Title: P38 activation induces the dissociation of tristetraprolin from Argonaute 2 to increase ARE-mRNA stabilization.
    Author: Qi MY, Song JW, Zhang Z, Huang S, Jing Q.
    Journal: Mol Biol Cell; 2018 Apr 15; 29(8):988-1002. PubMed ID: 29444957.
    Abstract:
    ARE-mRNAs are actively degraded with tristetraprolin (TTP) in resting cells while they turn into stable messengers in activated cells. P38 plays a crucial role in stabilizing ARE-mRNA. Here we reveal that P38 activation represses the interaction between TTP and Ago2, thus restraining TTP from being targeted into processing bodies and stabilizing ARE-mRNA.
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