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  • Title: T lymphocyte subsets and antilymphocyte antibodies in lupus nephritis.
    Author: Patel R, Patel DR, Najera D.
    Journal: Clin Nephrol; 1986 Aug; 26(2):83-6. PubMed ID: 2944680.
    Abstract:
    T lymphocyte subsets were determined in 12 patients with untreated systemic lupus erythematosus (SLE) and in 14 healthy controls. Six out of 8 (75%) patients with lupus nephritis had reduction in the percentage of T helper cells and low helper: suppressor cell ratios compared with controls. None of the 4 patients without nephritis had low ratios. Cold-reactive anti-lymphocyte antibodies cytotoxic to both the helper and the suppressor cells were detected in 7 of the 8 patients who had nephritis. Low T helper: suppressor cell ratio in SLE seems to correlate with the presence of active nephritis.
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