These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Characterization of suppressor-inducer cells which control the production of rat erythrocyte-induced anti-erythrocyte autoantibodies.
    Author: Watt GJ, Elson CJ, Healey DG, Oryan A, Hooper DC.
    Journal: Eur J Immunol; 1986 Sep; 16(9):1131-6. PubMed ID: 2944749.
    Abstract:
    Mice immunized with rat erythrocytes produce autoantibodies to their own red blood cells, distinct anti-rat agglutinins and autoantigen-specific suppressor cells. Suppressor cells were detected by adoptive transfer of rat erythrocyte-immunized spleen cells to naive recipients. Such recipients failed to make erythrocyte autoantibodies after immunization with rat erythrocytes although their anti-rat erythrocyte response was unimpaired. Depletion and enrichment studies were performed to identify the cell type(s) which transfer suppression. B cell depletion of rat erythrocyte-immunized spleen cells by passage over Ig/anti-Ig-coated bead columns abrogated the transfer of suppression. However, suppression was still transferred after rat erythrocyte immunized spleen cells were passed over beads coated with a complex of 4-azido-2-nitrophenyl (NAP)-mouse IgG-rabbit IgG anti-NAP suggesting that T cells bearing Fc gamma receptors are not responsible for suppression. Positively selected B cells from rat erythrocyte-immunized spleen cells caused some suppression of erythrocyte autoantibodies but only after high numbers of cells were transferred. Neither positively selected Lyt-1+2- nor Lyt-1-2+ T cell subpopulations transferred suppression. By contrast, rat erythrocyte-immunized spleen cells which contained a mixture of B memory and T cells were suppressive and retained their suppressor activity after removal of Lyt-1-2+ but not Lyt-1+2- cells. It is proposed that these Lyt-1+2-T cells belong to a distinct population of suppressor-inducer cells which together with memory B cells stimulate the generation of effector T suppressor cells in naive recipients.
    [Abstract] [Full Text] [Related] [New Search]