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  • Title: Megastigmane glycosides from Urena lobata.
    Author: Su C, Qi B, Wang J, Ding N, Wu Y, Shi XP, Zhu ZX, Liu X, Wang XH, Zheng J, Tu PF, Shi SP.
    Journal: Fitoterapia; 2018 Jun; 127():123-128. PubMed ID: 29447980.
    Abstract:
    Five new megastigmane glycosides, urenalobasides A-E (1-5), together with 11 known ones (6-16) were isolated from Urena lobata. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism method. Compounds 1 and 2 are two unusual megastigmanes structurally containing a 6/5 fused ring system. Compound 3 exhibits inhibition of nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC50 value of 53.7 ± 1.0 μM (positive control, dexamethasone, IC50 = 16.6 ± 0.8 μM).
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