These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy.
    Author: Mastropasqua R, Agnifili L, Borrelli E, Fasanella V, Brescia L, Di Antonio L, Mastropasqua L.
    Journal: Curr Eye Res; 2018 Jun; 43(6):778-784. PubMed ID: 29451992.
    Abstract:
    PURPOSE: To analyze the retinal radial peripapillary capillary (RPC) network in normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) eyes using optical coherence tomography angiography (OCTA). MATERIAL AND METHODS: Twenty-two patients with NTG, 22 patients with unilateral chronic NAION, and 23 age-matched controls were enrolled. Patients underwent OCTA to obtain en face angiograms of the peripapillary region. The main outcome measures were as follows: (1) the whole en face image perfusion density (WPD) and (2) the circumpapillary perfusion density (CPD). RESULTS: Mean ± SD age was 66.3 ± 7.0 years in the NTG group, 68.1 ± 4.3 years in the NAION group, and 63.9 ± 7.0 years in the control group (p > 0.05 for all the comparisons). The visual field mean defect (MD) was worse in patients than in controls (p < 0.0001), but did not differ between NTG and NAION (-9.6 ± 2.6 dB and -8.2 ± 2.6 dB, respectively). The WPD was 0.41 ± 0.04 in the NTG group (p < 0.0001 in comparison with healthy subjects and NAION patients), 0.46 ± 0.04 in the NAION group (p < 0.0001 in comparison with the control group), and 0.56 ± 0.03 in the control group. The CPD was significantly reduced in both NTG (0.48 ± 0.04, p < 0.0001) and NAION eyes (0.52 ± 0.05, p < 0.0001), after comparison to control eyes (0.59 ± 0.03). Moreover, the CPD was significantly lower in NTG than in NAION eyes (p = 0.006). CONCLUSIONS: OCTA documented a reduction of the peripapillary perfusion in NTG and unilateral NAION. In presence of similar functional damage, the lower perfusion densities in NTG may indicate greater vascular alterations in chronic compared to acute ischemic optic neuropathies.
    [Abstract] [Full Text] [Related] [New Search]