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  • Title: Atrial natriuretic peptide mRNA is regulated by glucocorticoids in vivo.
    Author: Gardner DG, Hane S, Trachewsky D, Schenk D, Baxter JD.
    Journal: Biochem Biophys Res Commun; 1986 Sep 30; 139(3):1047-54. PubMed ID: 2945558.
    Abstract:
    In these studies glucocorticoids were found to increase the plasma levels of atrial natriuretic peptide (ANP) as well as the expression of the ANP gene in the Sprague-Dawley rat. Plasma ANP rose two-fold after 48 hrs. of exposure to dexamethasone (1 mg/day) in both intact and adrenalectomized animals. This was accompanied by a 1.5-2.0 fold increase in the levels of atrial and ventricular ANP transcripts. Deoxycorticosterone acetate (5 mg/day), administered on the same schedule, failed to increase either plasma ANP levels or cardiac ANP mRNA accumulation. These effects suggest that ANP may have a potential role as a mediator of glucocorticoid activity in the cardiovascular system and support the hypothesis that ANP is a glucocorticoid-regulated gene.
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