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  • Title: [Delayed hypersensitivity reaction to transplantation antigens in mice with induced tolerance for allo- and xenografts].
    Author: Liadova IV, Cherniakhovskaia IIu, Golan V.
    Journal: Biull Eksp Biol Med; 1986 Oct; 102(10):452-5. PubMed ID: 2945600.
    Abstract:
    The delayed-type hypersensitivity reaction (DTH) in mice tolerant to allo- and xenoantigens has been investigated. To induce tolerance adult mice were thymectomized and given 1 X 10(8) allogeneic or xenogeneic spleen cells and cyclophosphamide (200 mg/kg). Such mice failed to develop DTH to donor antigens, while DTH reaction to foreign allo- and xenoantigens was retained. Spleen cells of mice tolerant to alloantigens significantly suppressed the afferent and efferent DTH phases. The suppression was specific and T-cell-mediated. Spleen cells of mice tolerant to xenoantigens could suppress only the afferent DTH phase. The treatment of cells with anti-T-globulin and complement did not abrogate the suppression. The role of DTH suppressors in the induction and maintenance of transplantation tolerance is discussed.
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