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  • Title: [The effect of the biologically active additive epiphamine on antioxidant and NADPH-generating enzymes activity under experimental cerebral ischemia/reperfusion in rats].
    Author: Popova TN, Safonova OA, Stolyarova AO, Verevkin AN.
    Journal: Biomed Khim; 2018 Jan; 64(1):31-37. PubMed ID: 29460832.
    Abstract:
    The effect of biologically active additive with immunomodulator properties epiphamine on the activity of antioxidant (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase) and NADPH-generating (glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase) enzymes has been investigated at experimental cerebral ischemia/reperfusion in rats. The results obtained indicate epiphamine-induced changes of these enzymes activities towards control values. Changes in the content of lactate, a marker of the pathology development, have also been found in experimental animals under ischemia and epiphamine administration caused changes similar to those observed in the case of enzyme activities studied. In most cases, the changes were dose-dependent. Thus, epiphamine can be of considerable interest from the point of view of metabolic changes pharmacological correction at the development of the pathology accompanied by oxidative stress. Provedeno issledovanie vliianiia biologicheski aktivnoĭ dobavki (BAD) s immunomoduliatornym deĭstviem épifamina na aktivnost' antioksidantnykh (superoksiddismutazy, katalazy, glutationperoksidazy, glutationreduktazy, glutationtransferazy) i NADPH-generiruiushchikh (gliukozo-6-fosfatdegidrogenazy, NADP-izotsitratdegidrogenazy) fermentov pri éksperimental'noĭ ishemii/reperfuzii golovnogo mozga u krys. Polucheny rezul'taty, svidetel'stvuiushchie ob izmenenii v storonu kontrol'nykh znacheniĭ vozrastaiushchikh pri patologii aktivnosteĭ dannykh fermentov, chto mozhet byt' sopriazheno s normalizatsieĭ oksidantno-antioksidantnogo balansa pri korrektsii urovnia melatonina. U éksperimental'nykh zhivotnykh takzhe bylo vyiavleno snizhenie vozrastaiushchikh pri ishemii soderzhaniia laktata – markernogo pokazatelia razvitiia patologii, parametrov biokhemiliuminestsentsii i urovnia produktov lipoperoksidatsii pri vvedenii épifamina na fone razvitiia patologicheskogo sostoianiia, chto pozvoliaet predpolagat' proiavlenie testiruemym sredstvom neĭroprotektornykh svoĭstv, sviazannykh, vozmozhno, s blagopriiatnym vliianiem na intensivnost' svobodnoradikal'nogo okisleniia. V bol'shinstve sluchaev izmeneniia nosili dozozavisimyĭ kharakter. V sviazi s vysheskazannym épifamin mozhet predstavliat' interes s tochki zreniia korrektsii izmeneniĭ metabolizma pri razvitii patologii, soprovozhdaiushcheĭsia okislitel'nym stressom.
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