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  • Title: On the circulating form of atrial natriuretic factor.
    Author: Cantin M, Genest J, Thibault G, Gutkowska J, Garcia R, De Léan A, Schiffrin EL, Lazure C, Seidah NG, Chrétien M.
    Journal: Trans Assoc Am Physicians; 1985; 98():116-22. PubMed ID: 2946099.
    Abstract:
    Isolation and sequencing of IR-ANF from plasma reveal that the circulating form of ANF is a 28-amino acid peptide (Ser 99-Tyr 126) which inhibits basal aldosterone secretion from suspensions of rat zona glomerulosa cells to the same extent as synthetic Arg 101-Tyr 126. The same form (minus two N-terminal amino acids) (Arg 101-Tyr 126) has been isolated from culture media of atrial cardiocytes and sequenced. Structure activity studies of shorter, N- or C-terminally truncated versions of synthetic Arg 101-Tyr 126 show that the latter is the most potent one.
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