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  • Title: Selenium-induced enhancement of hematoporphyrin derivative phototoxicity in murine bladder tumor cells.
    Author: Tosk J, Lau BH, Myers RC, Torrey R.
    Journal: Biochem Biophys Res Commun; 1986 Nov 14; 140(3):1086-92. PubMed ID: 2946295.
    Abstract:
    The phototoxicity of hematoporphyrin derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where selenite alone was non-toxic. Sodium selenite enhanced the fluorescence emission of Hpd and augmented the Hpd-sensitized photooxidation of tryptophan. The data suggest that sodium selenite is able to disaggregate Hpd, thereby enhancing Hpd-sensitized phototoxicity.
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