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  • Title: Influence of mild acid hydrolysis on the antigenic properties of phase I Coxiella burnetii.
    Author: Schramek S, Brezina R, Kazár J.
    Journal: Acta Virol; 1978 Jul; 22(4):302-8. PubMed ID: 29469.
    Abstract:
    Mild acid hydrolysis of phase I Coxiella burnetii cells gradually cleaved off polysaccharide chains, which contain determinants of antigen 1, thus unmasking determinants of the diagnostically important antigen 2. This artificial phase I to phase II conversion was reflected by changed serological activity in the complement-fixation (CF) test and by changed nonspecific phagocytosis. The product of mild acid hydrolysis can serve as a complex diagnostic preparation, because it reacts in the CF test with antibodies directed to both C. burnetii antigens.
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