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  • Title: [Observation on serum γ-glutamyl transpeptidase levels of patients with subclinical schistosomiasis before and after pathogen treatment].
    Author: Shi-Ye L, Jun-Jun L, Li-Juan X.
    Journal: Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi; 2016 Apr 25; 28(5):596-597. PubMed ID: 29469504.
    Abstract:
    OBJECTIVE: To observe the changes of serum γ-glutamyl transpeptidase (GGT) levels before and after the pathogen treatment in patients with subclinical schistosomiasis, and explore its clinical value in the diagnosis and treatment of subclinical schistosomiasis. METHODS: Totally 109 patients with subclinical schistosomiasis, who were found in the endemic investigation of schistosomiasis in Ezhou City, were selected as the investigation subjects, and then they were treated with praziquantel. The serum GGT levels of the subjects before and after the treatment were detected and compared. RESULTS: Before the treatment, the average value of the GGT levels of the 109 patients was (48.1 ± 45.9) IU/L, among which, the GGT levels of 69 cases (63.3%) were normal, and the levels of 40 cases (36.7%) were increased. After the treatment, the average GGT level of the patients was (32.1 ± 23.4) IU/L, which decreased by 33.3% comparing with that before the treatment, and the difference had a statistical significance (U＝2.17, P = 0.01). The GGT levels of 65 patients decreased in different degrees. Among the 40 patients whose GGT levels had increased before the treatment, the GGT levels of 31 ones returned to the normal. CONCLUSIONS: The GGT level detection can accurately reflect the liver function in the patients with subclinical schistosomiasis, and also it has certain clinical application value to judge the liver function damage and recovery of the patients before and after the pathogen treatment. [摘要]目的 观察亚临床型血吸虫病患者病原治疗前后血清中γ-谷氨酰转肽酶 (GGT) 水平的变化, 探讨GGT在亚临 床型血吸虫病诊疗中的临床价值。方法 选择鄂州市血吸虫病查病中发现的109例亚临床型血吸虫病患者作为研究对 象, 采用吡喹酮进行病原治疗, 检测并比较治疗前后患者血清GGT水平。结果 109例患者治疗前GGT平均值为 (48.1 ± 45.9) IU/L, 其中正常者69例 (63.3%), 升高者40例 (36.7%) 。治疗后, 患者GGT平均值为 (32.1 ± 23.4) IU/L, 较治疗前 下降了33.3%, 前后差异有统计学意义 (U＝2.17, P = 0.01); 其中65例患者GGT水平有不同程度下降; 治疗前GGT水平 升高的40例患者中, 31例恢复正常。结论 GGT水平检测能较确切地反映亚临床型血吸虫病患者肝脏的功能状况, 且对于判断病原治疗前后患者肝脏功能受损及恢复情况具有一定的临床应用价值。.
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