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  • Title: [Correlation between high signal intensity in cerebrum nucleus on unenhanced T1-weighted MR images and number of previous gadolinium-based contrast agent administration].
    Author: Pei L, Xu J, Zhang M.
    Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban; 2017 May 25; 46(5):487-491. PubMed ID: 29488714.
    Abstract:
    OBJECTIVE: To explore the correlation between the number of previous gadolinium-based contrast agent administrations and high signal intensity (SI) in the cerebrum nucleus on unenhanced T1-weighted magnetic resonance images. METHODS: Thirty-nine patients who previously underwent at least three contrast-enhanced brain MRI examinations were enrolled in the study. The right globus pallidus, right thalamus, right dentate nucleus, pons and white matter of right frontal lobe were selected as region of interests (ROI). The mean SIs of the ROI were measured on unenhanced T1-weighted images. The SI ratios of globus pallidus, right thalamus, right dentate nucleus and pons to white matter were calculated, respectively. The correlation of SI ratio variation with the number of previous contrast agent administration and clinical features was analyzed with Spearman analysis. RESULTS: The dentate nucleus-to-white matter SI ratios of the last and first MRI scan were 1.113±0.136 and 1.014±0.096(P<0.01), respectively; while the SI ratio differences between the last and first MRI scan of globus pallidus-to-white matter, the thalamus-to-white matter and the pons-to-white matter were not significant (all P>0.05). The dentate nucleus-to-white matter SI ratio was correlated with the number of previous gadolinium-based contrast agent administrations (r=0.329, P<0.05), but not with age, sex, underlying disease, treatment and history of diabetes (all P>0.05). CONCLUSIONS: High SI in the dentate nucleus on unenhanced T1-weighted images may be a consequence of the number of previous gadolinium-based contrast agent administrations. 目的: 探讨磁共振平扫T 1加权像脑内核团信号强度变化与钆对比剂注射次数的相关性。 方法: 回顾性分析在浙江大学医学院附属第二医院行头颅磁共振增强检查至少三次的39例患者的临床资料。分别选取右侧苍白球、右侧丘脑、右侧齿状核、桥脑、右侧额叶白质作为感兴趣区，测量每次检查时这些区域的平均信号强度，并以额叶白质的信号强度为基数计算各个核团的信号强度比。采用配对样本 t检验比较首次与末次检查苍白球、丘脑、齿状核及桥脑信号强度比差异；采用Spearman相关性检验分析感兴趣区信号强度比与磁共振增强检查次数及其他临床因素的相关性。 结果: 齿状核信号强度比在末次检查明显高于首次检查（1.113±0.136与1.014±0.096， P < 0.01）；而苍白球、丘脑、桥脑信号强度比在首次检查和末次检查间差异无统计学意义（均 P>0.05）。齿状核信号强度比与磁共振增强检查次数成正相关（ r=0.329， P < 0.05），与年龄、性别、主要疾病、治疗方式、糖尿病史无相关性（均 P>0.05）。 结论: 多次注射钆对比剂与小脑齿状核T 1加权像高信号可能相关。
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