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Title: Opsin accumulation in photoreceptor inner segment plasma membranes of dystrophic RCS rats. Author: Nir I, Sagie G, Papermaster DS. Journal: Invest Ophthalmol Vis Sci; 1987 Jan; 28(1):62-9. PubMed ID: 2948935. Abstract: Opsin localization in photoreceptor plasma membrane was studied in 10- to 30-day-old dystrophic RCS rats. Preembedding cytochemical procedures with antiopsin antibodies and electron microscopy were employed. In the second postnatal week, opsin was sequestered to the outer segment plasma membrane in affected rat retinas. This distribution resembled that observed in the photoreceptors of normal rats at this age. As unphagocytosed debris accumulated in the subretinal space, the outer segments degenerated, and the distribution of opsin in the plasma membrane changed. Opsin reappeared in the inner segment plasma membrane as the outer segments were lost. Loss of the regionalized distribution of opsin was not associated with visible ultrastructural changes in the inner segments or connecting cilium. Severely damaged cells invariably were labeled on their inner segments at high density. Thus, the presence of an outer segment was correlated with the clearance of opsin from the inner segment, while damage to the outer segment was followed by reappearance of opsin in the inner segment plasma membrane.[Abstract] [Full Text] [Related] [New Search]