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  • Title: [Clinical therapy of Zisheng decoction recipe for chronic atrophic gastritis with intestinal metaplasia].
    Author: Wu XX, Li X, Dang ZQ, Luo WZ, Zhao CP, Yu K.
    Journal: Zhongguo Zhong Yao Za Zhi; 2017 Dec; 42(24):4882-4887. PubMed ID: 29493162.
    Abstract:
    To explore the therapeutic effect and security of Zisheng decoction recipein treatment of the chronic atrophic gastritis (CAG) with intestinal metaplasia(IM). A total of 147 eligible cases were randomly divided into the traditional Chinese medicine group, Western medicine group and the combined group,47 cases in each group. Zisheng decoction recipe, famotidine, as well as Zisheng decoction recipe + famotidine were respectively given in the above three groups, with a treatment course of 30 d. The symptoms of traditional Chinese medicine, pathological score of gastric mucosa and the negative rate of Helicobacter pylori before and after treatment were observed in each group.The changes in pepsinogen Ⅰ (PGⅠ), pepsinogen Ⅱ (PGⅡ), gastrin-17 (GAS-17) and endothelin-1 (ET-1)were also detected to compare the efficient and safety indexes in the three groups. The combined group was better than the traditional Chinese medicine groupand the Western medicine group in total effective rate (P<0.05), pathological score of gastric mucosa and the negative rate of Helicobacter pylori, and serum indexes improvement (P<0.05). The improvement in TCM symptom score was more obvious in traditional Chinese medicine group and combined group than the Western medicine group (P<0.05). In the comparison ofincidence of complications,heart, liver and renal dysfunction, the traditional Chinese medicine group (2 case,4.8%)< the combined group (7 case,15.2%) <the Western medicine group (20 case,41.3%) (P<0.05). In the comparison of the blood and urine routine: the traditional Chinese medicine group (7 case,16.7%)< the combined group (14 case,30.4%) < the Western medicine group (24 case,52.2%) (P<0.05).The results showed that there was no significant difference in total effective rate between Zisheng decoction recipe and Western medicine in the treatment of CAG with IM, indicating Zisheng decoction recipe was effective; meanwhile, it had higher safety than famotidine. Zisheng decoction recipe combined with famotidine showed synergistic effect in the treatment of CAG with IM, can reverse the pathological changes of gastric mucosa in a certain extent, and the effect was better than that of Zisheng decoction recipe alone and famotidine alone.
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