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  • Title: [Effects of perfusion of human atrial natriuretic factor in normal volunteers].
    Author: Bidiville J, Waeber G, Nussberger J, Biollaz J, Porchet M, Waeber B, Brunner HR.
    Journal: Schweiz Med Wochenschr; 1986 Dec 06; 116(49):1733-5. PubMed ID: 2949362.
    Abstract:
    The renal and systemic effects of a synthetic atrial natriuretic peptide (ANP) corresponding to the sequence of the human hormone was investigated in normal volunteers. Each subject was infused for 4 hours on 3 different days at a one week interval with either ANP (0.5 or 1 microgram/min) or its vehicle. ANP enhanced natriuresis without simultaneously modifying glomerular filtration rate. ANP did, however, reduce effective renal plasma flow. In spite of the increased natriuresis, the activity of the renin-angiotensin-aldosterone system was reduced during ANP infusion. ANP induced a transient increase in skin blood flow. No change in blood pressure and heart rate occurred in the course of the experiment.
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