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  • Title: IgG binding to endothelial cells in systemic lupus erythematosus.
    Author: Le Roux G, Wautier MP, Guillevin L, Wautier JL.
    Journal: Thromb Haemost; 1986 Oct 21; 56(2):144-6. PubMed ID: 2949388.
    Abstract:
    Endothelial-associated IgG were determined in 20 patients with systemic lupus erythematosis (SLE)-8 of whom had a lupus anticoagulant (LA) and 6 a history of thrombosis. The binding of IgG present in patient plasma to cultured human endothelial cells was detected using radiolabeled staphylococcal protein A. Thirteen samples gave positive results and a significant association between endothelial-associated IgG and lupus anticoagulant was found (p less than 0.05). No statistically significant relationship with a previous history of thrombosis was found. These results suggest that the lupus anticoagulant may be directly involved in immune vascular injury induced by either antibodies or immune complexes in SLE.
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