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  • Title: A turn-on chemiluminescence biosensor for selective and sensitive detection of adenosine based on HKUST-1 and QDs-luminol-aptamer conjugates.
    Author: Lin Y, Dai Y, Sun Y, Ding C, Sun W, Zhu X, Liu H, Luo C.
    Journal: Talanta; 2018 May 15; 182():116-124. PubMed ID: 29501130.
    Abstract:
    In this work, HKUST-1 and QDs-luminol-aptamer conjugates were prepared. The QDs-luminol-aptamer conjugates can be adsorbed by graphene oxide through π-π conjugation. When the adenosine was added, the QDs-luminol-aptamer conjugates were released from magnetic graphene oxide (MGO), the chemiluminescent switch was turned on. It was reported that HKUST-1 can catalyze the chemiluminescence reaction of luminol-H2O2 system in an alkaline medium, and improve the chemiluminescence resonance energy transfer (CRET) between chemiluminescence and QDs indirectly. Thus, the adenosine can be detected sensitively. Based on this phenomenon, the excellent platform for detection of adenosine was established. Under the optimized conditions, the linear detection range for adenosine was 1.0 × 10-12-2.2 × 10-10 mol/L with a detection limit of 2.1 × 10-13 mol/L. The proposed method was successfully used for adenosine detection in biological samples.
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