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  • Title: Direct measurement of anterior corneal curvature changes attributable to epithelial removal in keratoconus.
    Author: Ziaei M, Meyer J, Gokul A, Vellara H, McGhee CNJ.
    Journal: J Cataract Refract Surg; 2018 Jan; 44(1):71-77. PubMed ID: 29502621.
    Abstract:
    PURPOSE: To compare the tomography of the corneal epithelium and Bowman layer in eyes with moderate to severe keratoconus before and after epithelial debridement. SETTING: University hospital tertiary referral center. DESIGN: Prospective case series. METHODS: Dual-channel Scheimpflug combined with Placido-disk tomography was used to measure the corneal variables in eyes with keratoconus having corneal crosslinking immediately before and after epithelial debridement. The differences in pachymetry, axial keratometry, astigmatism magnitude, asphericity, total corneal power, and spherical aberrations were computed. RESULTS: The study comprised 30 eyes of 30 patients. After epithelial removal, the central (0.0 to 4.0 mm) and midperipheral (4.0 to 7.0 mm) corneal zones were significantly thinner mean (21 μm ± 14 [SD] and 35 ± 44 μm, respectively). The mean anterior axial flat keratometry (K) (+1.71 diopters [D]), steep K (+2.14 D), maximum K (+2.13 D), corneal astigmatism (+1.11 D), asphericity (-0.31), and total corneal power changes (+2.03 D) were significantly different after epithelial debridement. There were no significant changes in posterior corneal flat K or steep K, posterior corneal astigmatism, or posterior asphericity. There were no significant differences in the mean astigmatic axis (anterior or posterior corneal surface) or spherical aberration after epithelial debridement. CONCLUSIONS: In eyes with moderate to severe keratoconus, the tomography of Bowman layer was significantly steeper than that of the epithelium; thus, epithelial debridement increased the magnitude of anterior corneal keratometry, astigmatism, and prolateness. These data suggest that the corneal epithelium smooths the underlying Bowman layer irregularity in keratoconus.
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