These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Asymmetric Total Synthesis of Lancifodilactone G Acetate. 1. Diastereoselective Synthesis of CDEFGH Ring System.
    Author: Sun TW, Liu DD, Wang KY, Tong BQ, Xie JX, Jiang YL, Li Y, Zhang B, Liu YF, Wang YX, Zhang JJ, Chen JH, Yang Z.
    Journal: J Org Chem; 2018 Jul 06; 83(13):6893-6906. PubMed ID: 29508610.
    Abstract:
    The stereoselective construction of the CDEFGH ring system of lancifodilactone G is described. The key steps in this synthesis are (i) ring-closing metathesis for formation of the oxa-bridged eight-membered ring; (ii) an intramolecular Pauson-Khand reaction for construction of the sterically congested F ring; and (iii) sequential cross-metathesis, hydrogenation, and lactonization reactions for installation of the anomerically stabilized bis-spiro ketal fragment of lancifodilactone G.
    [Abstract] [Full Text] [Related] [New Search]