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  • Title: Progression of impaired glucose tolerance to diabetes mellitus in patients with primary glaucoma and ocular hypertension.
    Author: Clark CV, Mapstone R.
    Journal: Diabet Med; 1986 May; 3(3):226-9. PubMed ID: 2951174.
    Abstract:
    In 375 patients aged 68.5 +/- 9.4 years (mean +/- 1 SD) with primary glaucoma subdivided by irido-corneal angle configuration into closed-angle glaucoma (123 cases), ocular hypertension (186 cases), and open-angle glaucoma (66 cases), diabetic status was determined by standard 75 g oral glucose tolerance tests. In 63 patients with impaired glucose tolerance who were retested one year later, 16% had progressed to diabetes mellitus. The results confirm a significant association between non-insulin dependent diabetes mellitus and primary glaucoma which may result from autonomic dysfunction in parasympathetic tone causing anterior chamber angle closure.
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