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  • Title: Copper-Catalyzed Regio- and Enantioselective Aminoboration of Unactivated Terminal Alkenes.
    Author: Kato K, Hirano K, Miura M.
    Journal: Chemistry; 2018 Apr 17; 24(22):5775-5778. PubMed ID: 29512216.
    Abstract:
    A CuCl/(R,R)-PTBP-BDPP-catalyzed regioselective and enantioselective aminoboration of simple and unactivated terminal alkenes with bis(pinacolato)diboron (pinB-Bpin) and hydroxylamines has been developed. The amino group and boryl group were incorporated at the internal position and terminal position, respectively, and the corresponding chiral β-borylalkylamines were obtained with good to high enantiomeric ratios. The asymmetric copper catalysis allows rapid and concise transformation of readily available olefinic feedstock-like materials into functionalized chiral alkylamines of high potential in medicinal and pharmaceutical chemistry.
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