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  • Title: Eculizumab reversed severe distal ischemic syndrome and glomerulonephritis with isolated C3 deposits associated with anti-factor H autoantibodies: a case report.
    Author: Deshayes S, Martin Silva N, Chatelet V, Chantepie S, Le Quintrec M, Comoz F, Bridoux F, Dragon-Durey MA, Aouba A.
    Journal: Clin Rheumatol; 2018 Apr; 37(4):1119-1122. PubMed ID: 29516279.
    Abstract:
    B-cell clones can produce a monoclonal immunoglobulin, which may be responsible for visceral involvements. Kidney involvement is frequent, affecting 20 to 50% of patients with multiple myeloma. One mechanism underlying this involvement is a dysregulation of the complement alternative pathway, leading to C3 glomerulopathies. We report a patient who had a multiple myeloma, C3 glomerulopathy related to factor H autoantibody, and digital ischemia, who was treated successfully with eculizumab, an anti-complement therapy, without any relapse in 2 years of follow-up.
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