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  • Title: Clinical physiological data on the bronchodilator effect of Duovent versus salbutamol in chronic obstructive lung disease.
    Author: Marangio E, Pesci A, Mori A, Marchioni M, Bertorelli G.
    Journal: Respiration; 1986; 50 Suppl 2():165-8. PubMed ID: 2951798.
    Abstract:
    We studied the bronchodilator effect of a combination of fenoterol (100 micrograms) and ipratropium bromide (40 micrograms) (Duovent) versus salbutamol and placebo in 16 patients with chronic obstructive lung disease (COLD). FEV1 and the side-effects (palpitations, tremors, excitation) were measured at 0, 30, 60, 120, 240, 360 and 420 min after administration. The drugs were administered in aerosol form following a randomization schedule. The bronchodilator effect of Duovent was greater than that of salbutamol; moreover, Duovent had a lasting efficacy and few side-effects. Duovent is thus a useful drug therapeutically.
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