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  • Title: Studies on the peroxisomal oxidation of palmitate and lignocerate in rat liver.
    Author: Wanders RJ, van Roermund CW, van Wijland MJ, Schutgens RB, Schram AW, van den Bosch H, Tager JM.
    Journal: Biochim Biophys Acta; 1987 May 13; 919(1):21-5. PubMed ID: 2952173.
    Abstract:
    We have investigated the pathways involved in the peroxisomal oxidation of palmitate and lignocerate, measured as the cyanide-insensitive formation of acetyl units, in rat-liver homogenates. The peroxisomal beta-oxidation of both fatty acids is dependent on the presence of ATP, coenzyme A, NAD+ and Mg2+. However, there is a striking difference in the dependence of the rate of oxidation of the two substrates on the concentration of the individual cofactors, especially ATP. The peroxisomal beta-oxidation of lignocerate was inhibited to a progressively greater extent by increasing concentrations of palmitate and vice versa. Activation of lignoceric acid to lignoceroyl-CoA, however, was not inhibited by increasing concentrations of palmitate, and vice versa. It can be concluded that the peroxisomal palmitate and lignocerate beta-oxidation pathways differ in at least one enzymic reaction (the synthetase), but that the two pathways share at least one common step.
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