These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: On the role of magnesium in the reaction of the pyruvate kinase from Salmonella typhimurium.
    Author: Garcia-Olalla C, Garrido-Pertierra A.
    Journal: Z Naturforsch C J Biosci; 1986; 41(11-12):1018-22. PubMed ID: 2953122.
    Abstract:
    The kinetics of the two purified forms of pyruvate kinase from Salmonella typhimurium LT-2 were studied in assays at pH 6.8 where the relationships between the initial velocities of the catalysed reactions and Mg2+ are non-hyperbolic. The analysis show that Mg2+ display positive homotropic interactions in their binding behaviour with Hill coefficient values of 2.5 and 1.2 for the form I and II, respectively. The binding sites of the cation to the pyruvate kinases seem to be independent to those for phosphoenolpyruvate and adenosine 5'-diphosphate; changes in the magnesium concentration might be of physiological significance in relation to a rapid regeneration of adenosine 5'-triphosphate by means of the pyruvate kinase reaction.
    [Abstract] [Full Text] [Related] [New Search]