These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Human T cell subsets.
    Author: Beverley PC.
    Journal: Immunol Lett; 1987 Apr; 14(4):263-7. PubMed ID: 2953677.
    Abstract:
    Several monoclonal antibodies (mAbs) demonstrate further heterogeneity of CD4 and CD8. Within CD4, two major subsets can be identified with helper/inducer and suppressor/inducer functions. It is argued that suppressor/inducers, identified by CD45R mAbs, are immature or virgin T cells and therefore respond poorly to recall antigens. Helper/inducers are CD45R negative but express the UCHL1 antigen, which appears to be part of CD45. These cells respond well to recall antigens and are therefore mature or memory T cells. Several antigens not related to CD45, such as 4B4, Leu8, TQ1 and 9.3, identify functionally distinct subsets rather than stages of T cell maturation.
    [Abstract] [Full Text] [Related] [New Search]