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  • Title: [Acanthosis nigricans maligna and Leser-Trélat sign in double malignancy of the breast and stomach].
    Author: Stieler W, Plewig G.
    Journal: Z Hautkr; 1987 Mar 01; 62(5):344-66. PubMed ID: 2954309.
    Abstract:
    A female patient with primary cancer of the breast and the stomach developed acanthosis nigricans maligna and Leser-Trélat's sign. Acanthosis nigricans maligna is a well-known cutaneous marker of internal malignancy. It may be intensified by radiotherapy. A variant is called florid cutaneous papillomatosis. Leser-Trélat's sign is a rare cutaneous marker of internal neoplasms. According to the literature, we present 46 patients showing Leser-Trélat's sign. Neither Leser nor Trélat described this sign.
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