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  • Title: Beta-endorphin amplifies the effect of interleukin-1 on mouse mesangial cell proliferation.
    Author: Ooi BS, MacCarthy EP, Hsu A.
    Journal: J Lab Clin Med; 1987 Aug; 110(2):159-63. PubMed ID: 2955065.
    Abstract:
    We report experiments that show that beta-endorphin, a neuropeptide, enhances the effect of interleukin-1 on mouse mesangial cell proliferation. Met-enkephalin, which comprises the first five amino acids of the beta-endorphin molecule, can also be shown to possess similar biologic activity. This action of beta-endorphin and met-enkephalin is mediated through naloxone-insensitive receptors on the mesangial cell, because naloxone treatment of the kidney cells does not abrogate this activity. The studies delineate a novel mechanism by which a neuropeptide may influence the development of immune-mediated cellular pathology.
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