These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood.
    Author: Shapiro R, Kim Y, Michael AF, Gerrard JM, Nesbit M, Coccia P, Ramsay NK, Krivit W.
    Journal: Am J Pediatr Hematol Oncol; 1979; 1(1):5-7. PubMed ID: 295575.
    Abstract:
    Serum complement studies were carried out in five children with acute lymphocytic leukemia. During therapy with L-asparaginase, prednisone and vincristine, hypocomplementemia developed in all patients, and disappeared within 2 weeks after the discontinuation of L-asparaginase. Complement breakdown products were not present in plasma. The changes of serum complement levels paralleled those of plasma fibrinogen. These findings suggest that the hypocomplementemia observed in these patients may be related to impaired protein synthesis induced by L-asparaginase.
    [Abstract] [Full Text] [Related] [New Search]