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  • Title: Fentanyl and the beta-endorphin, ACTH and glucoregulatory hormonal response to surgery.
    Author: Lacoumenta S, Yeo TH, Burrin JM, Bloom SR, Paterson JL, Hall GM.
    Journal: Br J Anaesth; 1987 Jun; 59(6):713-20. PubMed ID: 2955804.
    Abstract:
    The effect of the supplementation of nitrous oxide-oxygen anaesthesia with either fentanyl 15 micrograms kg-1 or 0.5% halothane on the beta-endorphin, ACTH, glucoregulatory hormonal and metabolic response to pelvic surgery was investigated. Fentanyl inhibited the increases in circulating beta-endorphin, ACTH, growth hormone, cortisol and glucose concentrations found in the patients receiving halothane. Changes in circulating beta-endorphin concentrations during surgery probably reflect alterations in pituitary secretion and appear to have no major metabolic effects. The suppression of pituitary secretion persisted for at least 4 h after the start of surgery.
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