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  • Title: Immunohistochemistry and immunocytochemistry of atrial natriuretic polypeptide in porcine heart.
    Author: Toshimori H, Toshimori K, Oura C, Matsuo H.
    Journal: Histochemistry; 1987; 86(6):595-601. PubMed ID: 2956221.
    Abstract:
    Specific granules in porcine hearts were observed in atrial cardiocytes, Purkinje fibers, and transitional cells of the ventricle. These granule-containing cells were immunohistochemically stained by applying the avidin-biotin-peroxidase complex method using an antiserum against alpha-human atrial natriuretic polypeptide (ANP). Immunoelectron microscopy of sections stained using the immunogold method indicated that these specific granules are storage sites of ANP. Furthermore, an impulse-conducting system consisting of immunoreactive cells was clearly distinguishable from nonimmunoreactive ventricular cardiocytes. We conclude that specific-granule-containing cells, i.e., ANP-producing cells, are located in both the atrial walls and the ventricular impulse-conducting system. The presence of ANP may be correlated with impulse conduction.
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