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  • Title: Optogenetic Control of Voltage-Gated Calcium Channels.
    Author: Ma G, Liu J, Ke Y, Liu X, Li M, Wang F, Han G, Huang Y, Wang Y, Zhou Y.
    Journal: Angew Chem Int Ed Engl; 2018 Jun 11; 57(24):7019-7022. PubMed ID: 29569306.
    Abstract:
    Voltage-gated Ca2+ (CaV ) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV -mediated physiological processes.
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