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  • Title: In vivo studies on the utilization of mono-L-aspartyl chlorin (NPe6) for photodynamic therapy.
    Author: Nelson JS, Roberts WG, Berns MW.
    Journal: Cancer Res; 1987 Sep 01; 47(17):4681-5. PubMed ID: 2957047.
    Abstract:
    The in vivo photosensitizing efficacy of mono-L-aspartyl chlorin has been studied by determining the percentage of BALB/c mice cured at varying doses of drug. Using an EMT-6 tumor model, animals received i.p. injections of mono-L-aspartyl chlorin (0.5-100 mg/kg) and then were subsequently exposed to light at 664 nm. Tumor biopsies were taken from selected animals sacrificed at 24 h after treatment and routine histopathological sections made. The other animals remained in the dark for a period of 6 weeks to determine the cure rate. Our results show that mono-L-aspartyl chlorin is an effective tumor localizer that brings about the selective degradation of tumor tissue following light exposure.
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