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  • Title: Suppression of cell proliferation after incubation of allogeneically stimulated mouse lymphocytes with concanavalin A: serological analysis of cell subpopulations involved.
    Author: Hückel C, Kusnierczyk P, Pajtasz E, Brock J.
    Journal: Folia Biol (Praha); 1987; 33(3):191-9. PubMed ID: 2957244.
    Abstract:
    The effect of Con A incubation of allogeneically stimulated lymphocytes (a-MLC) on cell proliferation was tested in three experimental systems: in the a-MLC cell population itself; after transfer of a-MLC cells to a culture of normal spleen cells with Con A; and after transfer of supernatants from cultures of a-MLC cells with Con A to fresh cultures of normal spleen cells with Con A. It was found that incubation with Con A to fresh cultures of normal spleen cells with Con A. It was found that incubation with Con A caused inhibition of cell proliferation in all three systems, indicating the generation of suppressor cells by incubation of a-MLC cells with Con A. The suppressive activity was abolished by cytotoxic treatment with either anti-Thy-1 or anti-Lyt-1 monoclonal antibodies, but neither with anti-L3T4 nor with anti-Lyt-2 antibodies, in all three systems.
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