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  • Title: Oxidative stress as a possible mechanism of statin-induced myopathy.
    Author: Ahmadi Y, Ghorbanihaghjo A, Naghi-Zadeh M, Yagin NL.
    Journal: Inflammopharmacology; 2018 Jun; 26(3):667-674. PubMed ID: 29574631.
    Abstract:
    Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants.
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