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  • Title: Chloroquine-induced cardiomyopathy.
    Author: McAllister HA, Ferrans VJ, Hall RJ, Strickman NE, Bossart MI.
    Journal: Arch Pathol Lab Med; 1987 Oct; 111(10):953-6. PubMed ID: 2957973.
    Abstract:
    Biventricular hypertrophy and failure developed in two patients during treatment of systemic lupus erythematosus with chloroquine phosphate. In both patients, morphologic analysis of the myocardium, obtained by a right ventricular endomyocardial biopsy in one patient and at autopsy in the other, revealed accumulations of electron-dense concentric and parallel lamellae and curvilinear bodies within cardiac myocytes. These deposits were similar to those reported in chloroquine-induced skeletal myopathy and were considered to represent evidence of chloroquine-induced cardiotoxicity rather than a cardiovascular manifestation of the underlying disease. Clinical awareness and an endomyocardial biopsy specimen are necessary for the appropriate diagnosis of chloroquine-induced cardiomyopathy.
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