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  • Title: Generalized lymphatic anomaly successfully treated with long-term, low-dose sirolimus.
    Author: Dvorakova V, Rea D, O'Regan GM, Irvine AD.
    Journal: Pediatr Dermatol; 2018 Jul; 35(4):533-534. PubMed ID: 29582448.
    Abstract:
    Generalized lymphatic anomaly is a rare, complex, lymphatic anomaly generally involving soft tissues, spleen, and bones. It can lead to focal skeletal fragility and pathologic effusions. A recent prospective trial of sirolimus for complicated vascular anomalies showed partial response in seven patients with generalized lymphatic anomaly treated with sirolimus with a target trough level of 10-15 ng/mL for 1 year (Adams et al). We describe successful treatment of generalized lymphatic anomaly with a lower-dose, long-term course of sirolimus.
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