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  • Title: Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes.
    Author: Saalmüller A, Reddehase MJ, Bühring HJ, Jonjić S, Koszinowski UH.
    Journal: Eur J Immunol; 1987 Sep; 17(9):1297-301. PubMed ID: 2958295.
    Abstract:
    The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4+CD8- T lymphocytes, respectively, two unusual subpopulations were prominent not only in peripheral blood, but also in lymphoid tissues: CD4-CD8- T lymphocytes expressing neither of these antigens and CD4+CD8+ T lymphocytes coexpressing both antigens. While CD4+CD8+ lymphoblasts have been found also in other species, resting T lymphocytes with that phenotype are without precedent among all species analyzed to date. This unique composition of the porcine T lymphocyte population has to be taken into consideration when the swine is used as a large animal model in experimental medicine.
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