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  • Title: Pancratium triflorum Roxb. (Amaryllidaceae) and Molineria trichocarpa (Wight) N.P. Balakr (Hypoxidaceae): Cytotoxic and antioxidant activities.
    Author: Johnson M, Maharaja P, Janakiraman N, Adaikala Raj G, Menezes IRA, da Costa JGM, Verde LCL, Coutinho HDM.
    Journal: Food Chem Toxicol; 2018 Sep; 119():290-295. PubMed ID: 29596974.
    Abstract:
    The present investigation was carried out to evaluate the antioxidant and cytotoxic activities of Pancratium triflorum Roxb and Molineria trichocarpa were collected from South Vagaikulam, Tirunelveli district, Tamil Nadu, India. The antioxidant activities of P. triflorum extracts were as follows with the IC50 values methanol (228.13 μg/mL) > chloroform (311.33 μg/mL) > acetone (398.08 μg/mL) > petroleum ether (410.16 μg/mL). The antioxidant activities of P. triflorum and M. trichocarpa extracts were as follows with the IC50 values methanol (80.93 μg/mL) > acetone (98.02 μg/mL) > chloroform (186.84 μg/mL) > petroleum ether (209.64 μg/mL). Among the various extracts of P. triflorum, methanolic extracts showed the strongest phosphomolybdenum reduction (140.56 g AA/100 g). Among the tested extracts, acetone extracts of M. trichocarpa showed maximum inhibition with 71.36 ± 5.86%. In P. triflorum, chloroform extracts showed maximum inhibition (69.51%). The petroleum ether extract of M. trichocarpa was found to be most effective at which 50% mortality (LC50) and 90% mortality (LC90) of brine shrimp nauplii were found to be 29.22 and 184.82 mg/mL. This study results revealed the antioxidant and cytotoxic properties of P. triflorum and M. trichocarpa. Further investigations are needed to isolate and validate the active principles of the extract responsible various pharmacological properties.
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