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  • Title: The effect of endotoxin on peripheral blood lymphocytes in the rat.
    Author: Cohen J, Faulkner L, Bowman C, Green C, Aslam M.
    Journal: J Clin Lab Immunol; 1987 Aug; 23(4):175-7. PubMed ID: 2959785.
    Abstract:
    We have studied the effects on peripheral blood lymphocytes of the administration to rats of a single dose of endotoxin. Lymphopenia occurred during the first hour, and persisted during 24 hours. Lymphocyte subpopulations were examined by flow cytometry. T-lymphocytes were relatively resistant to the initial effects of endotoxin, but there were no differences in the responses of cells identified as T-helper or T-suppressor/cytotoxic lymphocytes. The effects of endotoxin on peripheral blood lymphocytes is less extreme but appears more persistent than the effects on granulocytes.
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