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  • Title: MicroRNA-96 Promotes Tumor Invasion in Colorectal Cancer via RECK.
    Author: Iseki Y, Shibutani M, Maeda K, Nagahara H, Fukuoka T, Matsutani S, Hirakawa K, Ohira M.
    Journal: Anticancer Res; 2018 Apr; 38(4):2031-2035. PubMed ID: 29599320.
    Abstract:
    BACKGROUND: miR-96 is reported to inhibit reversion cysteine-rich Kazal motif (RECK), which is associated with tumor invasion, in solid cancer types (e.g. breast cancer, non-small cell lung cancer, esophageal cancer). The purpose of this study is to clarify whether miR-96 is similarly associated with tumor invasion in colorectal cancer. MATERIALS AND METHODS: We performed western blotting to investigate the expression of RECK when miR-96 mimics or inhibitors were transferred into HCT-116 colorectal cancer cells. The RECK mRNA level was assessed by a reverse transcription polymerase chain reaction. An invasion assay was used to evaluate tumor invasion. RESULTS: The expression of RECK was inhibited by the transfection of miR-96 mimics. RECK mRNA level was reduced by miR-96 mimics and increased by miR-96 inhibitor. In the invasion assay, miR-96 mimics were shown to promote tumor invasion. CONCLUSION: miR-96 may be associated with tumor invasion through inhibition of RECK expression in colorectal cancer.
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