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  • Title: [Locoregional chemotherapy of hepatic metastases of colorectal cancer].
    Author: Rougier P, Lasser P, Droz JP, Elias D, Ghosn M, Ducreux M, Lumbroso J, Sidibe S.
    Journal: Ann Gastroenterol Hepatol (Paris); 1987 Nov; 23(6):315-9. PubMed ID: 2962534.
    Abstract:
    Locoregional, intra-arterial chemotherapy of liver metastases secondary to colo-rectal cancers is the least damaging among non-surgical treatments. In our experience of 58 cases treated during three years either with intermittent perfusions of 5 FU, or with continuous perfusion of FUDR (by pump), we observed 52% and 53% of objective responses with a survival rate at one year, of 73% and 90% respectively. However, this technique is limited because of locoregional complications and less effective, due to the development of extra-hepatic metastases. The proof of its effectiveness, in terms of survival, is currently being studied in the scope of a prospective and randomized trial with control group.
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