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  • Title: Quadriceps concentric-eccentric force and muscle architecture in COPD patients vs healthy men.
    Author: Coratella G, Rinaldo N, Schena F.
    Journal: Hum Mov Sci; 2018 Jun; 59():88-95. PubMed ID: 29625361.
    Abstract:
    The aim of this study was to compare quadriceps concentric and eccentric strength and muscle architecture in chronic obstructive pulmonary disease (COPD) patients vs healthy men. Thirty-five COPD patients (age = 65 ± 4 yrs, forced expiratory volume (FEV1) = 63 ± 10%; FEV1/forced vital capacity (FVC)=57 ± 13% of predicted) and 25 age-matched healthy men (age = 65 ± 4 yrs, FEV1=114 ± 17%; FEV1/FVC = 101 ± 6% of predicted) (CON) participated in the present cross-sectional study. Concentric and eccentric isokinetic peak-torque was measured at low and high angular-velocity. Vastus lateralis pennation angle, fascicle length and muscle thickness were recorded using ultrasound device. Similar eccentric peak-torque was found in COPD and CON at low (2.57 ± 0.55 and 2.80 ± 0.60 N⋅m⋅kg-1, p = 0.128 respectively) and high (2.44 ± 0.51 and 2.58 ± 0.46 N⋅m⋅kg-1, p = 0.259) angular-velocity. Lower concentric peak-torque was found in COPD than in CON (p < 0.05). Smaller pennation angle (13.8 ± 3.4 vs 16.2 ± 3.9°) and muscle thickness (17.1 ± 2.8 vs 20.3 ± 3.0 mm) were found in COPD patients vs healthy men, with no difference in fascicle length. In COPD patients only, FEV1 and FEV1/FVC were negatively correlated with the eccentric-to-concentric peak-torque ratio (r = -0.465 and r = -0.414, respectively); irrespective of the testing-modality, FEV1 and FEV1/FVC were moderately correlated with peak-torque (p < 0.05). The preserved eccentric strength in COPD patients could be accounted for both mechanical and neural adaptations caused by the disease severity.
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