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  • Title: Acute Versus Chronic Ischemic Mitral Regurgitation: An Echocardiographic Study of Anatomy and Physiology.
    Author: Nishino S, Watanabe N, Kimura T, Kuriyama N, Shibata Y.
    Journal: Circ Cardiovasc Imaging; 2018 Apr; 11(4):e007028. PubMed ID: 29626079.
    Abstract:
    BACKGROUND: Little is known on the mechanism of acute ischemic mitral regurgitation (IMR) caused by sudden-onset left ventricular dysfunction in acute myocardial infarction (MI). We sought to investigate the mitral valve (MV) complex geometry in acute IMR in comparison with chronic IMR by 2-dimensional and 3-dimensional transthoracic echocardiography. METHODS AND RESULTS: Forty-four first-onset acute MI and 36 previous MI with ≥moderate IMR were examined by 2-dimensional/3-dimensional transthoracic echocardiography. MV morphology was quantitatively analyzed and compared between the 2 groups. Left ventricular end-diastolic volume and left ventricular end-systolic volume were significantly smaller in acute IMR than in chronic IMR (40.8 [33.1-48.3] versus 88.8 [66.5-108.8] mL/m2; P<0.001, 17.8 [17.0-30.1] versus 49.5 [34.2-73.7] mL/m2; P<0.001). MV tenting volume and annular area were significantly smaller in acute IMR compared with chronic IMR (0.98 [0.66-1.68] versus 1.88 [1.16-2.65] cm3/m2; P=0.008, 5.17 [4.80-5.86] versus 5.81 [5.47-8.22] cm2/m2; P=0.008). Leaflet surface area was significantly smaller in acute IMR than in chronic IMR (5.78 [5.16-6.32] versus 7.56 [6.89-11.32] cm2/m2; P<0.001). The ratio of MV leaflet surface area and MV annular area was significantly smaller in acute IMR than in chronic IMR (1.08 [1.01-1.14] versus 1.28 [1.24-1.37]; P=0.001). CONCLUSIONS: Sudden-onset left ventricular dysfunction in acute MI may cause loss of coaptation of the MV even with a relatively mild degree of valve tethering. Compared with previously studied chronic IMR, a smaller leaflet area without leaflet adaptation and a larger hemodynamic burden at the acute onset of MI could result in clinically significant IMR despite relatively small leaflet tethering.
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