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  • Title: What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients.
    Author: Aboumarzouk OM, Jones P, Amer T, Kotsiris D, Emiliani E, Somani B, Kallidonis P, Tailly T, Atis G, Greco F, Hruby S, Alvarez M, Al-Rumaihi K, Shamsodini A, Al-Ansari A, Shokeir A.
    Journal: Urology; 2018 Sep; 119():5-16. PubMed ID: 29626570.
    Abstract:
    Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.
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