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  • Title: Rapid Desensitization to Overcome Contrast Allergy Prior to Urgent Coronary Angiography.
    Author: Uppal S, DeCicco AE, Intini A, Josephson RA.
    Journal: Int Heart J; 2018 May 30; 59(3):622-625. PubMed ID: 29628477.
    Abstract:
    Allergic reactions to contrast media are a frequently reported complication of coronary angiography. The majority of patients experience mild, self-limited episodes, but in rare cases patients may experience severe, persistent symptoms. A strategy of premedication with corticosteroids and anti-histamines and an optimal selection of contrast agent is almost always successful in averting contrast reactions, yet a select few patients will continue to have breakthrough events. This is a case of recurrent, severe allergy to contrast media despite standard precautions complicating the treatment of non-ST elevation myocardial infarction (NSTEMI). Our patient was successfully managed with a strategy of rapid desensitization to iodinated contrast media achieved by administering progressively incremental doses of the media.
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