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Title: Clonidine in the treatment of premenstrual syndrome: a subgroup study. Author: Giannini AJ, Sullivan B, Sarachene J, Loiselle RH. Journal: J Clin Psychiatry; 1988 Feb; 49(2):62-3. PubMed ID: 2962993. Abstract: The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels. All of the women received clonidine and placebo in a double-blind cross-over design that spanned four menstrual cycles. Clonidine was significantly (p less than .05) more effective than placebo in reducing symptoms.[Abstract] [Full Text] [Related] [New Search]